Kadir Saleh, M. D., is an Assistant Professor, Research Associate and Chair, University of Melbourne, Australia, and co-author, The Global Cialis Prescription Drug, published by the National Center for Biotechnology Information and the National Institute of Health.
“We found that tadalafil (Cialis), the most widely used prescription medication, is also associated with increased risk of cardiovascular events and cardiovascular mortality,” said Saleh. “We are also exploring new research on the mechanisms and pathways of this association,” Saleh said.
Saleh was the first to report findings on the association of tadalafil (Cialis) with increased risk of cardiovascular events and cardiovascular mortality.
“This is the first study to link tadalafil (Cialis) with increased risk of cardiovascular events and mortality,” Saleh said. “This study is expected to be the first to demonstrate that tadalafil (Cialis) has an impact on cardiovascular disease risk in individuals with diabetes.”
Saleh was also a clinical research fellow at the University of Melbourne and co-author, A Study in Diabetes, and co-first author of the study. The study was funded by A/S, A/S/70/05, and the Australian Diabetes Association.
Saleh’s study involved 18,000 men aged 40-70 years with type 2 diabetes who received 10 mg of tadalafil once daily for 12 weeks, before a blood test for blood glucose. The participants then took a placebo tablet and received either 10 mg tadalafil once daily or a placebo tablet daily for another 12 weeks. The participants who took the tadalafil tablet were followed for a mean of 16.1 months.
During the follow-up period, the researchers found that tadalafil decreased the incidence of cardiovascular death, coronary heart disease, stroke, and type 2 diabetes.
“The results from this study demonstrate that tadalafil is an effective treatment for the prevention of cardiovascular disease and the prevention of cardiovascular mortality in patients with diabetes,” Saleh said.
The study was conducted in four countries: France, Italy, Germany, and Australia.
The researchers also reported that tadalafil, the most widely used prescription medication for erectile dysfunction, is associated with a small but significant increase in the risk of serious cardiovascular events.
Saleh said there was a need to investigate the effects of tadalafil on cardiovascular disease and mortality risk in patients with diabetes, particularly among older populations with underlying health problems such as high blood pressure and diabetes.
“The association of tadalafil with increased risk of cardiovascular events and mortality was established in an Australian study involving approximately 4,400 men with type 2 diabetes. The results of the study demonstrated that tadalafil is associated with a small but significant increase in the risk of cardiovascular events and mortality in this population,” Saleh said.
“Tadalafil should be used only under the supervision of a healthcare professional to achieve the best possible results for patients with diabetes, particularly for men who are at an increased risk for cardiovascular events and/or who are at a greater risk for adverse events such as cardiovascular death and stroke.”
A clinical research fellow at the University of Melbourne, Australia, and co-author, The Global Cialis Prescription Drug, published by the National Center for Biotechnology Information and the National Institute of HealthIn this abstract for this articleKey words:Cialis
Cialis, known generically as tadalafil, is a prescription medication that is used for the treatment of erectile dysfunction (ED). It is also available as a generic medication called Cialis.
Cialis is also used to treat benign prostatic hyperplasia (BPH), a condition in which the prostate gland becomes enlarged and painful. In BPH, the enlarged prostate makes it difficult for the bladder to empty and can lead to symptoms such as difficulty urinating, frequent urination, and frequent nighttime urination. Cialis is approved for use in adults and adolescents 12 years of age and older.
Cialis is available in 5 mg, 10 mg, and 20 mg strengths. The brand name Cialis has also been available as a generic medication. Cialis is not recommended for people who are allergic to any of its ingredients.
1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
If you experience any side effects or have trouble taking Cialis, please consult your doctor. They will need to provide Cialis with a doctor's diagnosis and treatment.atonin regulation system is a complementary hormone regulate blood flow to the penis, helping to manage sensitive individuals’ blood pressure levels.
Here are the key drug-food Inter interactions:
There are a lot of medications available in the South African market, and the drugstores that you find are generally unregulated.
Some of the most popular medications in South Africa are:
Sildenafil: The brand name of the drug is Viagra. It is a PDE5 inhibitor that works by relaxing the blood vessels, increasing blood flow to the penis during sexual stimulation. This helps you get and maintain an erection, making it easier to get and maintain an erection.
Tadalafil: The generic name is Cialis, and the brand name is it. Cialis is the brand name of Tadalafil and it is used to treat erectile dysfunction. It's an effective drug used to treat ED.
Sildenafil: The generic name is Vardenafil. It's the branded version of Viagra. It is the same drug as Viagra but the strength is different. It works by relaxing the blood vessels in the penis, allowing blood to flow into the penis when you are sexually aroused.
Sildenafil is used to treat benign prostatic hyperplasia (BPH). This is when the prostate gland is enlarged.
Sildenafil is also used to treat pulmonary arterial hypertension (PAH).
Tadalafil and Sildenafil are used to treat the signs and symptoms of erectile dysfunction.
It can also be used to treat the signs and symptoms of benign prostatic hyperplasia.
The recommended starting dose of sildenafil is one tablet about one hour before sexual activity. The dosage should be taken on an empty stomach, as it can take some time to work and take effect.
The dose for men can be reduced to one tablet a day.
Sildenafil is available in tablet form, which is usually taken 30 minutes to an hour before sexual activity. It is usually taken once a day.
Tadalafil is available in an immediate-release tablet form. It is taken once a day. The tablet form is usually taken 15 minutes before sex. It is usually taken on an empty stomach, as it can take some time to work and take effect.
Sildenafil is available in an extended-release tablet form.
The recommended starting dose of tadalafil is one tablet about one hour before sexual activity.
Sildenafil is also available in an extended-release tablet form.
The dose should be taken on an empty stomach, as it can take some time to work and take effect.
Sildenafil is available in an immediate-release tablet form.
Erection problems (impotence) are very common, particularly in men over 40.
Most men occasionally fail to get or keep an erection. This is usually due to stress, tiredness, anxiety or drinking too much alcohol, and it’s nothing to worry about.
If it happens more often, it may be caused by physical or emotional problems.
Physical causes Possible cause Treatment Narrowing of penis blood vessels, high blood pressure, high cholesterol medicine to lower blood pressure, statins to lower cholesterol Hormone problems hormone replacement – for example, testosterone Side effects of prescribed medication change to medicine following discussion with GP You may also be asked to make lifestyle changes.
Do lose weight if you’re overweight stop smoking eat a healthy diet exercise daily try to reduce stress and anxiety
Don’t cycle for a while (if you cycle more than 3 hours a week) drink more than 14 units of alcohol a week
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. These effects are normally mild to moderate in nature.
If you experience any of the following side effects stop using the medicine and seek medical help immediately:
allergic reactions including rashes (frequency uncommon). chest pain – do not use nitrates but seek immediate medical assistance (frequency uncommon). priapism, a prolonged and possibly painful erection after taking CIALIS (frequency rare). If you have such an erection, which lasts continuously for more than 4 hours you should contact a doctor immediately. sudden loss of vision (frequency rare). Other side effects have been reported:
Common (seen in 1 to 10 in every 100 patients)
headache, back pain, muscle aches, pain in arms and legs, facial flushing, nasal congestion, and indigestion. Uncommon (seen in 1 to 10 in every 1,000 patients)
dizziness, stomach ache, feeling sick, being sick (vomiting), reflux, blurred vision, eye pain, difficulty in breathing, presence of blood in urine, prolonged erection, pounding heartbeat sensation, a fast heart rate, high blood pressure, low blood pressure, nose bleeds, ringing in the ears, swelling of the hands, feet or ankles and feeling tired. Rare (seen in 1 to 10 in every 10,000 patients)
fainting, seizures and passing memory loss, swelling of the eyelids, red eyes, sudden decrease or loss of hearing, hives (itchy red welts on the surface of the skin), penile bleeding, presence of blood in semen and increased sweating. Heart attack and stroke have also been reported rarely in men taking CIALIS. Most of these men had known heart problems before taking this medicine.
Partial, temporary, or permanent decrease or loss of vision in one or both eyes has been rarely reported.
If you have partial or complete or partial or stroke or heart failure you are is not sure why you are between taking this medicine and the fever, so talk to your doctor: start taking CIALIS as soon as possible. When you usually need to take it more often, it is most common on days when the medicine is most effective.� ‘Days’ are right for Monday to Friday. It is not known if it is a percentage of daily dose on average. It is important to tell your doctor when you have had heart failure, liver or kidney failure, as they are considered typical.
Long term treatment is not known if you take it for extended periods of time. If you are treated with CIALIS for a long time, your effects may be limited.
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